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KMID : 0616120090400010046
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 1 p.46 ~ p.50
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Anti-proliferative Components in the Roots Extract from Pueraria thunbergiana
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Baek Mok-Ryeon
Choi Yeon-Hee
Yoo Dae-Seok
Kim Mi-Ri
Choi Sang-Un
Hong Kyung-Sik
Kim Young-Sup
Kim Young-Kyoon
Lee Kang-Ro
Ryu Shi-Yong
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Abstract
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The antitumor activity of the roots extract of Pueraria thunbergiana was investigated on the basis of cytotoxicity upon the cultured human tumor cell lines, in vitro. The purification of methylene chloride (MC) soluble part and ethylacetate
(EA) soluble part of extract by column chromatography furnished seven isoflavonoids, two triterpenoids, one but-2-enolide. The structures of them were established by chemical and spectroscopic means to be lupeol (1), β-sitosterol (2), biochanin A (3), (-)-tuberosin (4), calycosin (5), daidzein (6), puerarin (7), daidzin (8), (+)-puerol-B 2-O-β-glucopyranoside (9), formononetin-7-O-β-glucopyranoside (10). Each isolates (1~10) were evaluated for inhibitory activities on the proliferation of cultured human tumor cell lines such as A549, SK-OV-3, HCT-15 and SK-MEL-2, respectively.
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KEYWORD
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Pueraria thunbergiana, Leguminosae, Isoflavonoid, Cytotoxic activity
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